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The work is motivated by an industrial problem, which is alcohol removal from pharmaceutical process wastewater. The aim of the study was to develop a complete hybrid operation is investigated. Ethanol dehydration, in combination with distillation and hydrophilic pervaporation, is used to investigate about the extent of separation of the ethanol-water mixture. The aim of this research is to rigorously model and optimize this hybrid operation in professional flowsheet simulator environment. The number of minimal theoretical plates of distillation column and minimal effective membrane transfer area are determined. Cost estimation is also examined according to Douglas methodology. Considering our results it can be concluded that, the distillation and hydrophilic pervaporation processes are suitable for separation ethanol and water in 99.5 weight percent purity

Treatment of Pharmaceutical Process Wastewater with Hybrid Separation Method: Distillation and Hydrophilic Pervaporation