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Objectives Breast cancer is the second cause of death among women worldwide. In the last decades, the immunotherapy-based approaches have a growing importance in the treatment of breast cancer. Several studies have indicated the pleiotrophic effect of Interleukin-6 (IL-6) via targeting the membrane-bound or soluble receptors. Materials and methods Different concentrations of IL-6 were incubated for 24, 48, and 72 h in the breast carcinoma cell line (MCF-7). Cell proliferation, apoptotic cell population, gene expression by RT-PCR were measured, and the effect of IL-6 treatment on cell morphology was observed. Results In the present study, IL-6 treatment of MCF-7 cells inhibited cell proliferation in a dose and time dependent manner. The IL-6 treatment was found most effective on 24 h. The viable cell amount was decreased to 70.07 ± 4.85% at 100 nM treatment with a significant alteration on cell morphology, simultaneously in the 24 h of treatment. IL-6 treatment has also increased the early apoptotic cell population % in MCF-7 cells significantly (p&lt;0.0001). The RT-PCR analyses have shown that the apoptotic effect of IL-6 was related to the decrease at MMP-2/-9 mRNA levels (p&lt;0.0001). Conclusions In conclusion, IL-6 treatment may inhibit cell proliferation and induce apoptosis of MCF-7 cells in a dose-dependent manner through down-regulation of MMP-2/-9.

The confounding effect of interleukin-6 on apoptosis of MCF-7 cells through down-regulation of MMP-2/-9 mRNA expression