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Objective Intake of various fruits is quite significant for maintaining the human body, due to their supply of useful constituents.  V. opulus  has been found to have outstanding antioxidant activity while showing a pro-oxidant effect at high doses. Due to this feature,  V. opulus  would be anticipated to have a healing impact on cancer treatment. In this study, it has been proposed to examine the cytotoxic, genotoxic, and apoptotic effects of  V. opulus  on human colorectal cancer cell. Method Different concentrations of  V. opulus  methanolic extract (5–2000 μg/mL) were incubated for 24 h with colorectal cancer cell line (Lovo). The cell viability, intracellular reactive oxygen species (iROS), DNA damage, and apoptosis were measured after incubation. Results The obtained results of this research demonstrate decreased cell viability and increased DNA damage, iROS, and apoptosis levels of  V. opulus  in Lovo cells in a concentration-dependent manner in the range of 14.88–52.06%. There were strong positive relationships between apoptosis, genotoxicity, and cytotoxicity in  V. opulus  methanolic extract treated cancer cell line. Discussion This  in vitro  research clearly demonstrated that  V. opulus  methanolic extract induces DNA damage, apoptosis, and cytotoxicity in a dose-dependent manner in cancer cells due to its pro-oxidant activity. Conclusion Although  in vitro  results are favorable,  in vivo  and further studies are needed.

Cytotoxic, genotoxic and apoptotic effects of Viburnum opulus on colon cancer cells: an in vitro study