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B atch effect  R eduction of m I croarray data with  D ependent samples usin G    E mpirical Bayes ( BRIDGE ) is a recently developed statistical method to address the issue of batch effect correction in batch-confounded microarray studies with dependent samples. The key component of the  BRIDGE  methodology is the use of samples run as technical replicates in two or more batches, “bridging samples”, to inform batch effect correction/attenuation. While previously published results indicate a relationship between the number of bridging samples,  M , and the statistical power of downstream statistical testing on the batch-corrected data, there is of yet no formal statistical framework or user-friendly software, for estimating  M  to achieve a specific statistical power for hypothesis tests conducted on the batch-corrected data. To fill this gap, we developed  pwrBRIDGE , a simulation-based approach to estimate the bridging sample size,  M , in batch-confounded longitudinal microarray studies. To illustrate the use of  pwrBRIDGE , we consider a hypothetical, longitudinal batch-confounded study whose goal is to identify Alzheimer’s disease (AD) progression-associated genes from amnestic mild cognitive impairment (aMCI) to AD in human blood after a 5-year follow-up.  pwrBRIDGE  helps researchers design and plan batch-confounded microarray studies with dependent samples to avoid over- or under-powered studies.

pwrBRIDGE : a user-friendly web application for power and sample size estimation in batch-confounded microarray studies with dependent samples