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Agonists and antagonists of the 5-hydroxytryptamine (serotonin) receptor 6  (5-HT 6 ) or receptor 7  (5-HT 7 ) might improve memory and/or reverse amnesia, although the mechanisms involved are poorly understood. Hence, the current work summarizes recent reviews and findings involving these receptors. Evidence indicates that diverse 5-HT 6  receptor antagonists produce promnesic and/or antiamnesic effect in conditions, such as memory formation, age-related cognitive impairments and memory deficit in preclinical studies, as well as in diseases such as schizophrenia, Parkinson’s, and Alzheimer’s disease (AD). Memory, aging, and AD modify 5-HT 6  receptors and signaling cascades; likewise, the modulation of 5-HT 6  drugs on memory seems to be accompanied with neural changes. Moreover, 5-HT 7  receptors are localized in brain areas mediating memory, including the cortex, hippocampus (e.g., Zola-Morgan and Squire, 1993) and raphe nuclei; however, the role of these receptors on memory has yet to be fully explored. Hence, findings and reviews are summarized in this work. Evidence suggests that both 5-HT 7  receptor agonists and antagonists might have promnesic and anti-amnesic effects. These effects seem to be dependent on the basal level of performance, i.e., normal or impaired. Available evidence suggests that a potential utility of 5-HT 6  and 5-HT 7  receptor in mild-to-moderate AD patients and other memory dysfunctions as therapeutic targets.

Memory formation and memory alterations: 5-HT 6 and 5-HT 7 receptors, novel alternative