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This work focuses on tracking peptic ulcer localized in mice. The formation of a [ 99m Tc]dithiocarbamate of famotidine complex at optimum conditions of reaction temperature (37 °C), reaction time (30 min), pH of the reaction mixture (5), amount of substrate (100 µg), amount of reducing agent (tin (II) content, 50 µg), was achieved using radioactive Tc- 99m  (250–400 MBq), with labelling yield of 98% and high radiochemical purity. The  in-vitro  stability of [ 99m Tc]dithiocarbamate of famotidine complex was shown to be high in rat serum for up to 8 h. Normal and ulcerated mice were used in biodistribution studies. Famotidine works by blocking histamine-2-receptor antagonists (H 2 RAs). The high absorption of [ 99m Tc]dithiocarbamate of famotidine complex in stomach in amount of 27.15% injected dose/g organ (ID/g) observed in ulcerated mice for up to 24 h demonstrated its usefulness as a novel radiotracer for stomach imaging.

Preparation, characterization, and bioevaluation of 99m Tc-famotidine as a selective radiotracer for peptic ulcer disorder detection in mice