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Famotidine was labeled with iodine-125 to obtain  125 I-famotidine ( 125 I-fam) as an agent for ulcer imaging. The radiochemical yield of  125 I-famotidine reached approximately 98.5 ± 0.23% at optimum conditions of pH, oxidizing agent, reaction time and the amount of substrate.  125 I-fam was stable for 48 h. Different chromatographic techniques were used to determine the radiochemical yield and purity. Intravenous biodistribution studies of  125 I-fam revealed high concentration in the stomach ulcer, reaching about 65.9 ± 0.28% of the total injected dose at 30 min post injection. This concentration of  125 I-fam in stomach ulcer makes this agent promising for stomach ulcer imaging.

Radioiodinated famotidine as a new highly selective radiotracer for peptic ulcer disorder detection, diagnostic nuclear imaging and biodistribution