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90 Nb has an intermediate half-life of 14.6 h, a high positron branching of 53% and optimal  β  +  emission energy of only  E  mean  0.35 MeV per decay. These favorable characteristics suggest it may be a potential candidate for application in  immuno -PET. Our recent aim was to conduct studies on distribution coefficients for Zr IV  and Nb V  in mixtures of HCl/H 2 O 2  and HCl/oxalic acid for anion exchange resin (AG 1 × 8) and UTEVA resin to develop a “direct flow” separation strategy for  90 Nb. The direct flow concept refers to a separation accomplished using a single eluent on multiple columns, effectively streamlining the separation process and increasing the time efficiency. Finally, we also demonstrated that this separation strategy is applicable to the production of the positron emitter  90 Nb via the irradiation of molybdenum targets and isolation of  90 Nb from the irradiated molybdenum target.

Direct flow separation strategy, to isolate no-carrier-added 90 Nb from irradiated Mo or Zr targets