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This study describes the comparison between  99m Tc-tricarbonyl and  99m Tc-Sn (II) levosalbutamol as a  β  2 -adrenoceptors radiopharmaceutical and evaluation of their different biological characteristics using experimental animals. Levosalbutamol was labeled firstly with  99m Tc in the presence of SnCl 2  · 2H 2 O as a reducing agent under the optimum conditions: pH 8, 50 μg SnCl 2  · 2H–2O, room temperature, 40 μg levosalbutamol and 30 min reaction time to give a maximum radiochemical yield of 98 ± 0.1%. The obtained  99m Tc-levosalbutamol was stable for a time up to 8 h. Secondly,  99m Tc-tricarbonyl ([ 99m Tc(CO) 3 (H 2 O) 3 ] + ) levosalbutamol was prepare under 30 min heating at 100 ℃. Labeling yield and stability were analyzed by high performance liquid chromatography (labeling yield &gt;99% and stability for 8 h). Biodistribution investigation showed that, the maximum uptake ratio of the  99m Tc-levosalbutamol ( 99m Tc-Lev) between lung and heart was 2.34 ± 0.62 % of the injected activity/g tissue organ, at 30 min post-injection. But in case of  99m Tc-tricarbonyl levosalbutamol ( 99m Tc-tricarbonyl Lev) the maximum uptake ratio was 3.6 ± 0.11of the injected activity/g tissue organ, at 30 min post-injection. This indicates that  99m Tc-tricarbonyl levosalbutamol was more selective for lung  β  2 -adrenoceptors than  99m Tc-levosalbutamol. These results introduce  99m Tc-tricarbonyl levosalbutamol as a novel potential radiopharmaceutical for lung imaging.

Comparative biological evaluation between 99m Tc tricarbonyl and 99m Tc-Sn(II) levosalbutamol as a β 2 -adrenoceptor agonist