English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A potential dopamine D 4  receptor radioligand, 3-[4-(4-[ 18 F]fluorobenzyl)piperazin-1-ylmethyl]pyrazolo[1,5- a ]pyridine was synthesized through a one-pot two-step procedure with total yield 18.5% (decay corrected). The molar radioactivity was 115 GBq/ μ mol and the radiochemical purity was greater than 95.5%. Its affinity and selectivity for dopamine D 2 -like receptors were measured through  in vitro  receptor binding experiments and the  K   i   for D 4  receptor was determined to be 17 ± 0.5 nM. The partition coefficient (Log  P ) of it was determined to be 2.80 ± 0.10 through octanol experiment. The  in vivo  biodistribution of it in rat brain exposed that the radioligand penetrates through blood-brain- barrier (BBB) and may specifically bind to dopamine D 4  receptor. The results indicated that the radioligand shows promise for the  in vivo  study of dopamine D 4  receptor.

radiochimica acta

Radiochemical synthesis and biological evaluation of 3-[4-(4-[ 18 F]fluorobenzyl)piperazin-1-ylmethyl]pyrazolo[1,5- a ]pyridine as dopamine D 4  receptor radioligand