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The first human phaeochromocytorna cell line KNA was tested with regard to stimulation of dopamine biosynthesis by nicotinamide adenine dinucleotide (NADH). Differently from rat phaeochromocytoma cells - clone PC12, where NADH increased dopamine biosynthesis significantly, no stimulation in KNA cells was found. NADH is effective on speeding up the formation of the active cofactor tetrahydrobiopterin by a recycling pathway via the dihydropteridinreductase system. Another way of formation of tetrahydrobiopterin is the induction of de novo synthesis by cytokines such as interferon-y or by lipopolysaccharide via activation of GTP cyclohydrolase I, as shown in rnacrophages. Neither rat PC12 nor human KNA cells showed  in vitro  a  stimulation  of tetrahydrobiopterin de novo synthesis by interferon-y and/or lipopolysaccharide.

Effect of Interferon-γ and LPS on Tetrahydrobiopterin in Rat PC 12 and Human KNA Cells