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Neopterin, a compound derived from GTP, is a percursor molecule of biopterin and is an essential cofactor in neurotransmitter synthesis. It has recently reported that in vivo as well as in vitro immune responses are accompaniced by an increased release of neopterin and that this phenomenon can be used for the biochemical monitoring of diseases accompanied by hyperimmune stimulation. This article describes the immune response-associated neopterin release in the brain, and the possible involvement of microglia.

Neopterin In Immunological Reactions In Cancer and In the Brain Possible Involvement of Macrophages and Microglia