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Cold water immersion is thought to reduce the inflammatory response to injury. Using cultured mononuclear cells and human subjects in a mixed martial arts (MMA) contest, we examined the effect of cryotherapy on 7,8-dihydroneopterin and neopterin generation. Urine was collected from 10 elite male mixed martial artists before, immediately post and 1, 2, 24 and 48 h following a contest. Myoglobin was analysed by reverse-phase high performance liquid chromatography, and urinary neopterin and total neopterin (neopterin+7,8-dihydroneopterin) were measured by strong cation exchange high-performance liquid chromatography. Cold water immersion and passive recovery were compared using changes in these markers, while cryotherapy tested total neopterin production in γ-interferon and phorbol myristate acetate (PMA)-stimulated blood-derived mononuclear cells (monocytes/T cells). Myoglobin significantly increased (p&lt;0.05) at 1 h post-contest, neopterin significantly increased at 1 and 24 h (p&lt;0.05), total neopterin significantly increased (p&lt;0.05) at 1 h post for the passive group only, and significant individual variation was observed for all markers (p&lt;0.01). Cold water immersion attenuated total neopterin production (p&lt;0.05), while cryotherapy significantly reduced total neopterin production in PMA-stimulated mononuclear cells (p&lt;0.01). Cryotherapy attenuates the post-exercise inflammatory response following an MMA contest. The evidence also suggests that the mechanisms responsible for this may be related to direct immune cell suppression.

The physiological and mononuclear cell activation response to cryotherapy following a mixed martial arts contest: a pilot study