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Topical fungal infections including,  Tinea capitis  with escalating resistance to conventional therapies are a rising concern globally. Studies have shown substantial  in vitro  efficacy of plant compounds against fungal pathogens. This study utilized flavonoid glycosides from  Dicerocaryum senecioides and Diospyros mespiliformis  as active compounds to formulate a topical cream against  Tinea capitis . The  in vitro  test utilized disc diffusion assay prepared from fungal isolates obtained from individuals showing resistance to topical miconazole. Clinical trials were performed using volunteers. Both isolated strains exhibited substantial  in vitro  susceptibility to the cream formulation with inhibition zones ranging between 10 and 18 mm. MIC values for both test organisms ranged between 85 mg/ml and 120 mg/ml. The cream showed stability both physico-chemically and against microbial contamination. Physicochemical parameters evaluated include colour, pH, appearance, particle size, phase separation, phase inversion, creaming, spread-ability, electrical conductivity and  in vitro  occlusivity test and were within the accepted range. In limited clinical trials using volunteers,  Tinea capitis  started disappearing as from day 5 by topically applying the cream twice per day. All the patients were completely healed by the 7th day. The results of the study showed that flavonoid glycosides from  D. senecioides and D. mespiliformis  are good candidates to be utilized as active natural compounds against  Tinea capitis  resistant strains. Therefore more clinical trials and structural elucidations are recommended.

Formulation of a herbal topical cream against Tinea capitis using flavonoids glycosides from Dicerocaryum senecioides and Diospyros mespiliformis