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Phytochemical investigations on the dechlorophyllated extract of  Anthocleista schweinfurthii  Gilg (Loganiaceae) leaves have enabled the isolation of two xanthones derivatives: 1,8-dihydroxy-2,6-dimethoxyxanthone ( 1 ) and 1-hydroxy-3,7,8-trimethoxyxanthone ( 2 ) known, respectively, as swertiaperenin ( 1 ) and decussatin ( 2 ), but isolated here for the first time from this plant. The structures of these compounds were investigated by rigorous analysis of their one- and two-dimensional NMR spectral data. Compounds ( 1 ) and ( 2 ) were evaluated for their antioxidant activities using the 1,1-diphenyl-2-picrylhydrazyl method (DPPH°); the reducing power of iron III (FRAP) and antibacterial activity by the solid diffusion method on three bacteria strains ( Escherichia coli ,  Staphylococcus aureus,  and  Bacillus cereus ). The results obtained show that the two compounds have good antioxidant and antibacterial activities. Obviously, swertiaperenin and decussatin are among the active secondary’s metabolites responsible for the biological activity of  A. schweinfurthii  Gild recognized by the Cameroonian populations.

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Antioxidant and antibacterial activities of two xanthones derivatives isolated from the leaves extract of  Anthocleista schweinfurthii  Gilg (Loganiaceae)