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Artocarpus   kemando  Miq. is an Indonesian endemic plant rich in flavonoid compounds and bioactivity. Artonin E (compound 1), a flavonoid compound, was isolated from the branch and root bark of the indicated plant, obtained from Karang Anyar, Klaten, Penengahan, South Lampung. Compound  (1)  was then modified using diazomethane, which produced compound  (2) . Both compounds were then identified by TLC using standard compound, after which their UV–Vis, FT-IR,  1 H and  13 C NMR spectra were compared with literature data. Furthermore, the cytotoxicity assay of the compound  (1)  was determined using leukemia P-388 cancer cells, which showed a strong anticancer activity with IC 50  of 1.56 μg/mL. The antibacterial activity of this compound against  Bacillus subtilis  showed strong activity for 0.3 mg/disc concentration; compound  (2)  with 0.5 mg/disc concentration, while against  Escherichia coli , compound  (1)  showed moderate activity, while compound  (2)  did not show any activity.

Cytotoxicity test and antibacterial assay on the compound produced by the isolation and modification of artonin E from Artocarpus kemando Miq.