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Background and objectives:  Laser methods, such as laser-induced fluorescence diagnostics, photodynamic therapy (PDT), and hyperthermia, are finding increasing use in medicine. Irradiation can be performed both with and without contact on the tissue surface. In the case of contact irradiation, especially when laser radiation is introduced into biological tissue through an optical fiber, it is important to know the processes taking place at the irradiation fiber end. These processes affect diffusely reflected radiation which returns to the fiber. By analyzing backscattered radiation, we can evaluate the quality of the radiation procedure and the state of the fiber end. The objectives of this study were to develop a method and device for measuring backscattered radiation power and using this method, to determine the time and temperature ranges realized in PDT and hyperthermia.

photonics and lasers in medicine

Technique for measuring laser radiation intensity in biological tissues: Messverfahren zur Bestimmung der Intensität von Laserstrahlung in biologischen Geweben