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Medicinal plant  Cassia sieberiana  root bark was investigated for phytochemicals and Anti-Breast Cancer cells (MCF-7) properties, using Chemical Separations and MTT assay  in vitro . The  C. sieberiana  root bark was extracted with soxhlet extractor using different solvents based on polarity guided method and the respective extracts were concentrated under reduced pressure. These extracts were screened for their phytochemicals qualitatively using standard methods. Percentage Yields and Physico-Chemical Evaluation of the Extracts from the various fractions were recorded. The results of phytochemicals screening revealed the presence of some secondary metabolites of pharmacological significance in the Methyl acetate, MeOH and 70 % MeOH root bark extracts including  Saponins, Quinones, Phenolic, Steroids, Tannins, Flavounoids, Terpenoids, Anthraquinones, Cardiac-glycosides, Alkaloids, Carbohydrates, Glycosides and Coumarins . Results obtained from MTT assay revealed that Extracts of MeOH and 70 % MeOH samples shown a certain degree of inhibition towards MCF-7 cell line. IC 50  were calculated using Graph Pad Prism 6 and results shown that IC 50  of 245.3 μg/ml and 239.6 μg/ml dose dependent inhibitions in MCF-7 cells respectively, compared to  Oxaliplatin  IC 50  of 38.04 μg/ml. Therefore, 70 % MeOH sample with IC 50  of 239.6 μg/ml have shown more potential of inhibiting breast cancer cell, MCF-7 cells line. The inhibition of the root bark is attributed to some of the phytochemicals present in the plant.

MTT assay of human anti-breast cancer cells (MCF-7) in vitro potentials and phytochemicals screening of the root bark extracts from Cassia sieberiana