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The manual radiofluorination and purification of [FeF 3 (BnMe 2 -tacn)] (tacn = 1,4,7-triazacyclononane) using  18 F −  in aqueous EtOH has been translated to a GE FASTLab™ automatic synthesis platform and optimised by conducting a series of low-activity radiolabelling experiments to explore the effects of varying the precursor concentration, temperature, heating time, addition of NaOAc buffer and EtOH:H 2 O ratio. The optimal conditions were determined to be 1 mg/mL of the precursor being heated at 120 °C for 10 min in 75 %:25 % EtOH:H 2 O containing  18 F − , with elution using 10 mM NaOAc, giving 61 % radiochemical yield (RCY). These conditions were then employed with high-activity  18 F −  giving a 97 % radiochemical purity (RCP) at  t  = 0, which decreases by 22 % over 5 h. Sodium ascorbate, nicotinamide and  p -benzoic acid ( p ABA) were then tested as potential radiostabilisers for this system, initially using low-activity  18 F − . These experiments revealed very rapid defluorination of the radioproduct in the presence of sodium ascorbate. In contrast, both nicotinamide and  p ABA appear to be effective radiostabilisers, resulting in RCP values of 91 % and 89 %, respectively, after 2 h, which compare with an RCP of 81 % under analogous conditions at  t  = 2 h in their absence. High-activity experiments were then undertaken with addition of 5 mg/mL of nicotinamide, with a radio-active concentration (RAC) of 220 MBq/mL, giving RCY of 26 % and following purification, RCP values for the [Fe 18 FF 2 (BnMe 2 -tacn)] product of 97 % at  t  = 0 and 86 % after 3 h.

Automating the production of [Fe 18 FF 2 (BnMe 2 -tacn)] and investigating radiostabilisers for use with high-activity [ 18 F]F −