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. Body composition and body fat distribution show difference in women with Cushing's syndrome (CS) compared to healthy control women (C) with almost equal body mass index (BMI) (28.89±3.53kg/m2 vs. 29.39±4.04kg/m2) and they were compared with DXA. Methods. Total and regional fat mass (FM), FM%, tissue mass (TM), TM%, android FM (A), gynoid FM (G), lean body mass (LBM), bone mineral density (BMD) and content (BMC) were determined as well as their relationships in 10 CS and 10 C women. Results. Regional FM, FM%, TM and TM% values were not different between CS and C except for arm TM % (45.06±3.1% vs. 40.23±6.29%) (p<0.043). Arms+legs/trunk TM and FM ratio were significantly lower in CS compared to C (p<0.0001). Arms/A (1.1±0.12), legs/A (3±0.41) and legs/trunk TM ratios (0.52±0.07) were significantly lower in CS compared to C (1.3±0.13) (p<0.002), (4.29 ±0.67) (p<0.0001) and (0.69±0.09) (p<0.0001). Legs/A (2.57±0.73), legs/trunk (0.48±0.13) and arms+legs/trunk FM ratio (0.66±0.14) in CS were significantly lower compared to C [(4.2±1.16; 0.71±0.12 (p<0.001) and 0.89±0.14 (p<0.002)]. A/GTM (0.67±0.1) and A/G FM ratio (0.72± 0.2) in CS were significantly higher compared to C (0.48±0.05) (p<0.0001) and (0.46±0.09) (p<0.001). Legs LBM in CS 10.8±1.95kg was lower compared to C 12.7±2.1 kg (p<0.046). Only spine BMD value in CS (0.89±0.09 kg/cm2) was lower compared to C (0.94±0.12 kg/cm2) (p<0.017). Conclusion. Central to peripheral regional TM, FM and LBM ratios differentiated significantly and precisely patients with CS and C and confirmed extreme central obesity in CS.

Dual-Energy X - Rayabsorptiometry (Dxa) Assessment of Body Composition and Body Fat Distribution in Cushing’s Women