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Tetracycline ( TecH2) reacts with triphenylantimony ( TPSbiii) in the presence of hydrogen peroxide to form the [Ph 3 Sb v (Tec)] ( TecAn ). The sodium penicillin G ( PenH ) conjugates with Ag( i ) towards [Ag(Pen)(MeCN)] 2  ( PenAcAg ).  TecAn  and  PenAcAg  were characterized by melting point, X-ray fluorescence spectroscopy, attenuated total reflectance-Fourier transform infra-red, thermogravimetric-differential thermal analysis in solid state, ultraviolet-Vis spectroscopy, and nuclear magnetic resonance ( 1 H and  13 C-NMR), spectroscopies in solution. The molecular weight was determined with cryoscopy. The  in vitro  cytotoxic activity of  TecAn  and  PenAcAg  was evaluated against the human breast adenocarcinoma cell lines: MCF-7 (positive to hormones receptor (HR+)), MDA-MB-231 (negative to hormones receptor (HR−)), and their  in vitro  toxicity and genotoxicity were tested against normal human fetal lung fibroblast cells (MRC-5). The MCF-7 cells’ morphology and acridine orange/ethidium bromide staining suggest an apoptotic pathway for cell death. The binding affinity of  TecAn  and  PenAcAg  with DNA was, ex vivo, studied by UV-Vis and fluorescence spectroscopy and viscosity measurements of DNA solution.  PenAcAg  inhibits lipoxygenase (LOX) stronger than cisplatin, while no inhibitory activity has been detected for  TecAn . The reduction of non-active Sb( v ), of  TecAn , to active Sb( iii ) by glutathione (a tripeptide over expressed in tumor cells) was also investigated.

Conjugation of tetracycline and penicillin with Sb( v ) and Ag( i ) against breast cancer cells