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A novel lead (II) complex of Schiff base containing three bipyridine units was synthesized by the template reaction between a new amine compound, 6-methyl-6′-(2-aminophenoxymethyl)-2,2′-bipyridine, and 2,2′-bipyridine-6,6′-dicarboxaldehyde in the presence of a Pb(II) perchlorate ion. The new amino compound and Schiff base complex, [Pb L ](ClO 4 ) 2 ·2H 2 O, were characterized by using matrix-assisted laser desorption/ionization with time-of-flight mass spectroscopy, FAR FT-IR, UV/visible spectroscopy,  1 H NMR, elemental analyses (CHN), and molar conductivity measurements. Then the synthesized complex was screened  in vitro  for its antibacterial and antifungal activities against three Gram-negative and two Gram-positive bacteria and also against  Candida albicans  as a fungus by the microdilution broth method as a minimal inhibitory concentration. [Pb L ](ClO 4 ) 2 ·2H 2 O exhibits moderate activity on  Staphylococcus aureus  and  Listeria monocytogenes  when compared with standard drug and also shows moderate antifungal activity on the fungus  Candida albicans.

Template synthesis, characterization, and antimicrobial activity of a new lead (II) Schiff base complex