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Phosphodiesterase 4D interacting protein ( PDE4DIP ) interacts with cAMP-specific phosphodiesterase 4D and its abnormal expression promotes the development of hematological malignancies, breast cancer, and pineal cell carcinoma. However, there is currently no systematic pan-cancer analysis of the association between  PDE4DIP  and various cancers. Thus, this study aimed to elucidate the potential functions of  PDE4DIP  in various cancers. Based on the multiple public databases and online websites, we conducted comprehensive analyses for  PDE4DIP  in various cancers, including differential expression, prognosis, genetic variation, DNA methylation, and immunity. We thoroughly analyzed the specific role of  PDE4DIP  in acute myeloid leukemia (LAML). The results indicated that there were differences in  PDE4DIP  expression in cancers, and in kidney chromophobe, LAML, pheochromocytoma and paraganglioma, thymoma, and uveal melanoma,  PDE4DIP  had potential prognostic value.  PDE4DIP  expression was also correlated with genetic variation, DNA methylation, immune cell infiltration, and immune-related genes in cancers. Functional enrichment analysis showed that  PDE4DIP  was mainly related to immune-related pathways in cancers, and in LAML,  PDE4DIP  was mainly related to immunoglobulin complexes, T-cell receptor complexes, and immune response regulatory signaling pathways. Our study systematically revealed for the first time the potential prognostic and immunotherapeutic value of  PDE4DIP  in various cancers, including LAML.

Pan-cancer analysis of the PDE4DIP gene with potential prognostic and immunotherapeutic values in multiple cancers including acute myeloid leukemia