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Telomeres are located at the ends of chromosomes and consist of non-coding TTAGGG repeats and telomere-binding proteins. Telomeres protect the chromosomal ends from degradation, aberrant recombination and end-to-end fusion. Due to the end-replication problem, telomeres shorten with each round of replication  in vitro  and  in vivo , eventually leading to genetic instability and cellular senescence. In germline cells and in the majority of human cancers studied, telomere length is maintained by the enzyme telomerase, which adds terminal TTAGGG repeats onto the chromosome ends and thus counteracts replication-dependent telomere shortening.

laboratoriumsmedizin

Telomere length analysis by fluorescence in situ hybridization and flow cytometry (Flow-FISH)/Telomerlängen-Messung mittels Fluoreszenz-in-situ-Hybridisierung und Durchflusszytometrie (Flow-FISH)