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Background Serum sodium concentration could be spuriously reduced by excess glucose or lipid; thus, hyponatremia should be reassessed before reporting in order to exclude the possibility of pseudohyponatremia. Methods In this study, we used the calculation of corrected serum sodium concentration in hyperglycemic or lipemic samples and evaluated its effect on the reduction in frequency of reports on pseudohyponatremia. We retrospectively analyzed 1-year data from the laboratory information system. Results From August 2017 to July 2018, hyponatremia was initially noted in 30,465 results, of which 6614 results reported hyperglycemia. Corrected sodium concentrations were calculated using the results with glucose &gt;170 mg/dL or lipemia index ≥3. The reported frequency of hyponatremia before and after correction of sodium concentration was reduced by 42.9%. Moreover, only 51.9% of the patients with severe hyponatremia had “true” severe hyponatremia. After applying the formula, the degree of hyponatremia was unchanged in only 45.8% of the total results. Conclusions Our report on the corrected sodium concentration reduced the frequency of pseudohyponatremia in hyperglycemic samples. Calculation of corrected sodium concentration is a useful tool to help clinicians establish appropriate care and treatment plans. Further prospective study is required to validate to our system in a real clinical practice.

Effects of correction equation for actual sodium concentration on the reduction in frequency of reports on pseudohyponatremia