English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Early-onset inflammatory bowel disease (IBD) is classified into Crohn’s disease (CD), ulcerative colitis (UC) and unclassified disorders, which has a chronic, relapsing course and can result in substantial long-term morbidity. IBD is a multifactorial disorder with genetic susceptibility, immunological predisposition and environmental triggers. The objective of this study was to generally determine the prevalence of  IL10R  mutation in IBD patients in Isfahan, Iran. We performed sequencing of all exons in  IL10RA  and  IL10RB  in a cohort of IBD patients and healthy controls.    Methods  Total DNA contents of 76 patients and 50 healthy controls were extracted from whole blood and polymerase chain reaction (PCR) amplifications and sequencing of whole exons in IL10R were performed.    Results  Overall, we determined 13 single nucleotide polymorphisms (SNPs) in all  IL10R  genes. Of them, rs3135932 and rs2229113 of the  IL10RA1  gene, in exons 4 and 7, respectively, were significantly associated with IBD occurrence in patients.    Conclusions  Our results also confirmed that early-onset IBD could be attributed to a synergistic effect of several variant alleles of the genes encoding  IL10  receptors. These variants, alone, could only give rise to a sub-clinical manifestation of IBD.

An analysis and survey of interleukin-10 receptor mutation in inflammatory bowel disease (IBD) in the first Iranian IBD cohort