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The functions and mechanisms of prion proteins (PrP C ) are currently unknown, but most experts believe that deformed or pathogenic prion proteins (PrP Sc ) originate from PrP C , and that there may be plural main sites for the conversion of normal PrP C into PrP Sc . In order to better understand the mechanism of PrP C transformation to PrP Sc , the most important step is to determine the replacement or substitution site.

Exploration of the main sites for the transformation of normal prion protein (PrPC) into pathogenic prion protein (PrPsc)