English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Flower et a I ( 1 ) , reported that a s p i r i n treated, oxygen-exposed beagle p u p p i e s developed retinopathy of s i g n i f i c a n t l y greater severity than the i r unmedicated, oxygen-exposed Ii t termates. Direct ophthaImoscopic observations ind ica ted that whereas susta ined oxygen b rea th ing produced r e t i n a l vasoconstriction in unmedica ted p u p p i e s , r e t i n a l vessels of a s p i r i n treated Iittermates became d i l a t e d or remained unchanged. The authors conc luded that r e t i n a l vasoconstriction, i f v iewed as p h y s i o l o g i c and protective, may be a b o l i s h e d by a pros tagland i n synthetase i n h i b i t o r such as a s p i r i n , thereby a l l o w i n g a free f l o w of hyperoxic blood into r e t i n a l t issue c a u s i n g oxygen damage. Prompted by th i s observation, we reviewed our experience of the past 8 years to determine whether the use of indomethac in , a potent p r o s t a g l a n d i n synthetase i n h i b i t o r for closure of PDA, made any d i f f e r e n c e in the inc idence and severity of ROP in extremely low b i r t h weight i n f an t s .

Indomethacin and Retinopathy of Prematurity (ROP) in Infants with Patent Ductus Arteriosus (PDA)