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I n t r o d u c t i o n R o u t i n e morphologica l e x a m i n a t i o n of 3500 human placentas a n n u a l l y and the autopsy f i n d i n g s in cases of pe r ina t a l death mot iva ted us to inves t iga te if def ined p lacen ta l lesions produce pe r i na t a l b ra in damage. Several models fön short-term per ina t a l a sphyxia in rhesus-monkeys have been p u b l l s h e d (1 4). However, a n i m a l models demonst ra t ing the effect of def ined p l acen t a l i n f a r c t i on on the f e t a l b ra in are not avail a b l e . Therefore we devised a method to produce p lacen ta l infarc ts exper i men ta l l y .

Do placental infarcts produce perinatal brain damage?