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A response of lymphocytes in the neonatal period is different from that in later stages, and a capaN(Ncity for cellular immunity is reduced in infants with intrauterine growth retardation (IUGR) [6]. Although immune response of newborn infants is largely dependent on the intrauterine life, the relation between gestational age and lymphocyte activity has not yet been well established. To elucidate how the intrauterine life affects the immune response of neonates and at which moment those aberrant responses return to normal, we have studied spontaneous and phytohaemagglutinin (PHA)-induced blastogenesis of circulating lymphocytes from neonates and adults. (Experiment 1) Spontaneous blastogenesis of lymphocytes (SBL) from neonates was always greater than that of adults and the addition of autologous or homologous plasma did not affect their blastogenesis, suggesting that the greater responsibility of lymphocytes is an intrinsic characteristic [12]. However, the effect of monocytes could not be excluded, since monocytes are present in the lymphocyte culture. Then we depleted monocytes from mononuclear leucocytes (MNL) fraction and tested their effect on the lymphocyte blastogenesis. (Experiment 2)

Lymphocyte blastogenesis in normal and low birth weight infants and the effect of monocyte depletion on it