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In the course of a study on urinary estriol levels in preterm and term infants, creatinine determinations were performed as reference values to calculate estriol-creatinine ratios [3], Since Information on creatinine levels in newborns is not available over a wide range of birth weight and gestational age, we considered it worthwhile to give a separate report of these data. Creatinine reaches the urine almost exclusively, by glomerular filtration [1]. Thus endogenous creatinine clearance has been used as a means of assessing glomerular filtration capacity both in health and disease [1], In utero metabolism is at a more steady state than postnatally: There is a steady influx of nourishment via the umbilical vessels, physical activity is limited and it may be assumed that protein catabolism also is more constant and even than after birth [4], If these assumptions are in fact correct, a single urinary creatinine level reflecting such steady inutero conditions, would be sufficient to yield Information about the state of glomerular filtration capacity. The first urine passed after birth, would meet these criteria. McCANCE reported that glomerular filtration rate is markedly reduced in preterm infants [6]. This should be reflected in the creatinine levels with which this paper is concerned.

Creatinine levels in first urines of male preterm and term infants