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A drug to suppress uterine activity with minimal or no side eflfects would be valuable for the prevention of premature or precipitous labor, or for the control of tetanic uterine contractions. Recently it has been reported that diazoxide*, a benzothiadiazine derivative, a smooth muscle relaxant [15] inhibits myometrial activity of the human uterus [3, 9] with no apparent adverse reactions on the fetus [5, 8]. However, the dose necessary to suppres uterine activity also causes maternal hypotension [5] and the drug has other pharmacologic actions including the induction of hyperglycemia. Because of the lack.of direct Information on the effect of the drug on the fetus, pilot experiments were conducted in our laboratory on the pregnant guinea pig and her fetus [11], Blood glucose rose to a similar degree in both mother and fetus, and when delivered, the fetuses were acidotic and severely depressed, probably as a result of maternal hypotension. On the basis of these observations, it was feit that possible adverse effects of the drug on the fetus should be examined more carefully. This paper describes experiments on pregnant subhuman primates in which the inhibiting action of diazoxide on uterine activity, placental transfer of the drug and its effect on the cardiovascular and biochemical state of both mother and fetus were studied.

The inhibitory action of Diazoxide on uterine activity in the subhuman primate: Placental transfer and effect on the fetus