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Aims:  To measure plasma concentrations of endothelin (ET)-1, NO metabolites (nitrate/nitrite; NO x ) and 6-keto PGF 1α  (PGF 1α ) in maternal and fetal sheep blood, and to evaluate the effects of big ET-1 on hemodynamic response, blood gases and NO and 6-keto PGF 1α  production in near term fetal sheep.

Effects of nitric oxide and prostacyclin on hemodynamic response by big endothelin-1 in near term fetal sheep