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Aims:  During pregnancy, the placenta produces a variety of steroid hormones and proteins. Several of these substances have been shown to exert immunomodulatory effects. Progesterone is thought to mediate some of these effects by regulating uterine responsiveness. The aim of this study was to clarify the effect of amniotic fluid transferrin and its N-glycans on the release of progesterone by first trimester trophoblast cells  in vitro .

N-Glycans of human amniotic fluid transferrin stimulate progesterone production in human first trimester trophoblast cells in vitro