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A total of 20 children with benign transient hyperphosphatasemia were prospectively evaluated with no additional investigations recommended except repeat serologic evaluation in 2–3 months. The average age of our patients was 2.5 years (range: 1 year 2 months–5 years 10 months). The serum levels of alkaline phosphatase averaged 2383 IU/L (range: 1013–5700 IU/L). Levels returned to normal within several months. This condition should be recognized by the clinician in order not to put patients through lengthy, expensive and unnecessary investigations.

Benign transient hyperphosphatasemia in infants and children: a prospective cohort