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Atherothrombotic complications in insulin resistance are partly attributed to impaired fibrinolysis caused by increased PAI-1 plasma levels, and 4G/5G promotor polymorphism of the PAI-1 gene may modulate PAI-1 transcription.

Plasminogen Activator Inhibitor-1 (PAI-1) Gene Polymorphism (-675 4G/SG) Associated with Obesity and Vascular Risk in Children