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Obesity and insulin resistance are increasingly common problems in children. Tumor necrosis factor-alpha (TNF-alpha) has important effects on lipid and glucose metabolism. This effect may be mediated through soluble TNF-alpha receptor 2 (sTNFR2).

Serum Levels of Soluble Tumor Necrosis Factor-α Receptor 2 are Linked to Insulin Resistance and Glucose Intolerance in Children