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Sotos syndrome is an overgrowth syndrome of poorly understood aetiology. We investigated whether this syndrome is related to alterations in plasma insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), acid-labile subunit (ALS) and serum IGFBP-3 proteolysis.

journal of pediatric endocrinology and metabolism

Plasma Insulin-Like Growth Factors (IGFs), IGF-Binding Proteins (IGFBPs), Acid-Labile Subunit (ALS) and IGFBP-3 Proteolysis in Individuals with Clinical Characteristics of Sotos Syndrome