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Primary insulin-like growth factor-I (IGF-I) deficiencies, such as in Laron syndrome (LS), are a unique model in man to study the consequences resulting from defects in growth hormone (GH) signal transmission.

journal of pediatric endocrinology and metabolism

Effects of Insulin-like Growth Factor-I Deficiency and Replacement Therapy on the Hematopoietic System in Patients with Laron Syndrome (Primary Growth Hormone Insensitivity)