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Exercise training leads to tissue anabolism by acting through the growth hormone (GH)-insulin-like growth factor-I (IGF-I) axis, but the role of tissue IGF-I receptors in this process is not known. Erythrocyte IGF-I receptor binding is known to be affected by circulating levels of IGF-I. We hypothesized that training would lead to alterations in erythrocyte IGF-I binding. Thirty-eight adolescent males (mean age 16+/-0.7 yr) were randomized to a control (n=18) or endurance training intervention lasting 5 weeks. Erythrocyte IGF-I binding was measured by standard techniques. Quantity of receptor binding sites (R), binding affinity constant (Kaff), and nonspecific binding (NS) were calculated. Training led to increases (p&lt;0.05) in 1) Kaff x R - an index of overall binding capacity (control, 7.3 +/-8.0%; trained, 60+/-21%); and 2) NS (control, 1.5+/-6.6%; trained 23.2+/-7.5%). Kaff, R, and R/erythrocyte increased in trained subjects, but not significantly so. These results suggest a training-associated upregulation of IGF-I binding. Finally, the unexpected increase in NS may reflect IGF binding protein activity, rather than changes in the erythrocyte IGF-I receptors themselves.

Effect of Exercise Training on Erythrocyte Insulin-like Growth Factor-I Receptor Binding in Adolescent Males