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We evaluated a short, prepubertal 13.9 year-old boy with Blackfan-Diamond anemia and significant liver iron stores due to multiple blood transfusions and found him to have several endocrine abnormalities, including hypothyroidism, hypoparathyroidism, primary and secondary hypogonadism and IGF-I insufficiency. Growth velocity was poor despite treatment with levothyroxine, calcitriol, calcium and aggressive therapy with chelating agents. After 25 months of treatment with rhGH his growth velocity, height for age and PAH increased significantly, suggesting a degree of sensitivity to GH despite his liver damage.

journal of pediatric endocrinology and metabolism

Multiple Endocrine Abnormalities in a Child with Blackfan-Diamond Anemia and Hemochromatosis. Significant Improvement of Growth Velocity and Predicted Adult Height Following Growth Hormone Treatment Despite Liver Damage