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The past decade witnessed an increasing interest in assessing circulating DNA in the plasma and serum of patients with malignant and non-malignant diseases. This might be due to the availability of new and sensitive methods for the determination of qualitative and quantitative changes in circulating DNA. As, previously, tumor-specific mutations or epigenetic modifications have been detected predominantly in tissue specimens, the appealing possibility to use less invasive though specific methods for tumor diagnosis was a noticeable incentive for the exploration of circulating DNA.

Diagnostische Bedeutung zirkulierender DNA- Fragmente in der Onkologie. Diagnostic importance of circulating DNA fragments in oncology