Open AccessDifficulties of Mobilization and Harvesting of Hematopoietic Stem Cells in Heavily Pre-Treated Patients
Author(s) -
Erzsébet Lázár,
Judit-Beáta Köpeczi,
Enikő Kakucs,
István Benedek,
Szende Jakab,
Annamária Pakucs,
C. Tudor,
István Benedek
Publication year - 2017
Publication title -
journal of interdisciplinary medicine
Language(s) - English
Resource type - Journals
eISSN - 2501-8132
pISSN - 2501-5974
DOI - 10.1515/jim-2017-0028
Subject(s) - plerixafor , filgrastim , medicine , mobilization , multiple myeloma , stem cell , autologous stem cell transplantation , lymphoma , surgery , transplantation , haematopoiesis , hematopoietic stem cell transplantation , granulocyte colony stimulating factor , oncology , chemotherapy , cxcr4 , biology , history , receptor , archaeology , chemokine , genetics
This study presents a new method of combined growth factor mobilization with increased dose (15 μg/kg) of filgrastim and standard mono dose of plerixafor in subjects with multiple myeloma, Hodgkin or non-Hodgkin lymphoma. Efficient mobilization is a key factor in the treatment of this group of patients, because autologous transplantation can be performed in cases in which we succeed to obtain a minimally sufficient number of stem cells. Autologous stem cell transplantation is included in the current standard treatment of multiple myeloma and in the relapsed cases of lymphomas
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom