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Adipogenesis is the fat cell formation process regulated by peroxisome proliferator-activated receptors ( PPARγ ). The insulin-responsive glucose transporter 4 ( GLUT4 ) has a major role in glucose uptake and metabolism in insulin target tissues (i.e., adipose and muscle cells). The interplay between PPARγ and GLUT4 is essential for proper glucose homeostasis. This study aimed to isolate, elucidate, and investigate the effect of an isolated compound from Penicillium citrinum XT6 on adipogenesis, PPARγ , and GLUT4 expression in 3T3-L1 adipocytes.

journal of complementary and integrative medicine

Non-monotonic dose-response of di-(2-ethylhexyl) phthalate isolated from  Penicillium citrinum  XT6 on adipogenesis and expression of  PPARγ  and  GLUT4  in 3T3-L1 adipocytes