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Background : Rheumatoid arthritis is an inflammatory autoimmune disorder.  Withania somnifera  Dunal (Solanaceae) (WS), is a common medicinal plant used in traditional systems of medicine for the treatment of arthritis, and is an ingredient of anti-arthritic polyherbal formulations such as  Habb-e-Asgand  ®  and Arthritin™. In the present study, we evaluated the antioxidant and anti-arthritic activity of aqueous extract of WS root (WSAq) in collagen-induced arthritic (CIA) rats.

journal of complementary and integrative medicine

Effect of  Withania somnifera  (Ashwagandha) root extract on amelioration of oxidative stress and autoantibodies production in collagen-induced arthritic rats