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Reactive oxygen and nitrogen species may be produced during inflammation leading to the formation of NO, H 2 S or HNO. Enzymes such as iNOS, CSE and CBS might also be responsible for polysulfide production. Since these signalling molecules might have an impact on colonic motility, the aim of this study was to compare their effect on rat colonic slow phasic contractions (SPC).

journal of basic and clinical physiology and pharmacology

Complementary mechanisms of modulation of spontaneous phasic contractions by the gaseous signalling molecules NO, H 2 S, HNO and the polysulfide Na 2 S 3  in the rat colon