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In this clinical trial, the effect of aqueous extract of Berberis vulgaris L. was investigated on opiate withdrawal syndrome, depression, anxiety, stress, and sleep quality in opioid addicts which were under methadone maintenance therapy.

journal of basic and clinical physiology and pharmacology

The effects of  Berberis vulgaris  L. root extract on the opiate withdrawal syndrome and psychological factors: a randomized double-blind clinical trial