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Broad spectrum antimalarial drugs without deleterious effects on mitochondria are scarce. It is in this regard that we investigated the potency of methanol extract and solvent fractions of Phyllanthus amarus on chloroquine-susceptible and resistant strains of Plasmodium berghei , toxicity and its consequential effects on mitochondrial permeability transition (mPT) pore opening.

journal of basic and clinical physiology and pharmacology

Antimalarial properties and preventive effects on mitochondrial dysfunction by extract and fractions of  Phyllanthus amarus  (Schum. and Thonn) in  Plasmodium berghei -infected mice