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Background The present study used reactive oxygen species (ROS)-total antioxidant capacity (TAC) score to understand the role of redox status on the effect of Telfairia occidentalis (TO) on testicular parameters. The fatty acids (FAs) components of methanol extract of TO (METO) and its fractions were also identified with gas chromatography-mass spectrometry. Methods A total of 66 male Wistar rats were randomly divided in a blinded fashion into six oral treatment groups as follows: group I (control, n=6) received 10% ethanol (vehicle for TO administration). Groups II to VI (n=12 rats each) were subdivided into two treatment subgroups (n=6 each) that received 200 mg/kg and 600 mg/kg of METO and its chloroform, petroleum ether, acetone, and ethanol fractions, respectively. All treatments lasted for 30 days. Results The major FAs detected in TO were myristic, palmitic, oleic, linoleic, linolenic, and stearic acids including their esters. Both doses of METO and its fractions increased the semen parameters, TAC and ROS-TAC scores but decreased the ROS when compared with control. Conclusions Using the ROS-TAC score, this study suggests that TO-associated improvement in semen parameters might be partly mediated by a reduction in free radical generation, and that the FAs present in TO might be involved in its spermatoprotective effect.

journal of basic and clinical physiology and pharmacology

Role of reactive oxygen species–total antioxidant capacity status in  Telfairia occidentalis  leaves–associated spermatoprotective effect: a pointer to fatty acids benefit