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Studies with NF-IL6-deficient mice indicate that this transcription factor plays a dual role during systemic inflammation with pro- and anti-inflammatory capacities. Here, we aimed to characterize the role of NF-IL6 specifically within the brain.

journal of basic and clinical physiology and pharmacology

The use of siRNA as a pharmacological tool to assess a role for the transcription factor NF-IL6 in the brain under  in vitro  and  in vivo  conditions during LPS-induced inflammatory stimulation